Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), Truncated

Cat.No	ACP09997	Target Name	TNFSF18
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09997

Target Name

TNFSF18

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UNG2

Background Information

Uniprot Id

Q9UNG2
Target Species

Human
Target Name

TNFSF18
Target Full Name

Tumor necrosis factor ligand superfamily member 18
Target Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.
Target Protein Families

Tumor necrosis factor family
Target Tissue Specificity

Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
Target Synonyms

Activation inducible TNF related ligand; Activation-inducible TNF-related ligand; AITR ligand; AITRL; GITR ligand; GITRL; Glucocorticoid induced TNF related ligand; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; MGC138237; TL6; TNF18_HUMAN; TNFSF18; TNLG2A; Tumor necrosis factor (ligand) superfamily member 18; Tumor necrosis factor ligand 2A; Tumor necrosis factor ligand superfamily member 18
Target Background

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.

Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Tumor necrosis factor ligand superfamily member 18 (TNFSF18), Truncated Now

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