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| Cat.No | ACP00915 | Target Name | TNFRSF17 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Mammalian cell |
| Expression Range | 1-54aa | Mol Weight | 34.9 kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q02223 |
|---|
Uniprot Id
Q02223
Target Species
Human
Target Name
TNFRSF17
Target Full Name
Tumor necrosis factor receptor superfamily member 17
Target Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Target Involvement
A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Target Subcellular Location
Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
Target Tissue Specificity
Expressed in mature B-cells, but not in T-cells or monocytes.
Target Research Area
Cancer
Target Synonyms
BCM; BCMA; CD269; TNFRSF13A; TNFRSF17
Target Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
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