Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), Truncated

Uniprot Id

P25942

Target Species

Human

Target Name

CD40

Target Full Name

Tumor necrosis factor receptor superfamily member 5

Target Function

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

Target Involvement

Immunodeficiency with hyper-IgM 3 (HIGM3)

Target Subcellular Location

[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.

Target Tissue Specificity

B-cells and in primary carcinomas.

Target Research Area

Immunology

Target Synonyms

CD40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40

Target Background

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.