Recombinant Human Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)

Uniprot Id

O95407

Target Species

Human

Target Name

TNFRSF6B

Target Full Name

Tumor necrosis factor receptor superfamily member 6B

Target Function

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Target Subcellular Location

Secreted.

Target Tissue Specificity

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Target Synonyms

DcR3; Decoy receptor 3; Decoy receptor for Fas ligand; DJ583P15.1.1; M68; M68E; OTTHUMP00000031583 ; TNF6B_HUMAN; TNFRSF6B; TR6; Tumor necrosis factor receptor superfamily member 6B; Tumor necrosis factor receptor superfamily member 6b decoy; UNQ186/PRO212

Target Background

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.