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| Cat.No | ACP12138 | Target Name | TWSG1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 26-223 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9GZX9 |
|---|
Uniprot Id
Q9GZX9
Target Species
Human
Target Name
TWSG1
Target Full Name
Twisted gastrulation protein homolog 1
Target Function
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
Target Subcellular Location
Secreted.
Target Protein Families
Twisted gastrulation protein family
Target Synonyms
PSEC0250; twisted gastrulation homolog 1 (Drosophila); TSG; TSG1; Twisted gastrulation BMP signaling modulator 1; Twisted gastrulation homolog 1; Twisted gastrulation protein; Twisted gastrulation protein homolog 1; TWSG1; TWSG1_HUMAN
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