Recombinant Human Tyrosine-protein phosphatase non-receptor type 13 (PTPN13), Truncated

Cat.No	ACP18413	Target Name	PTPN13
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP18413

Target Name

PTPN13

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q12923

Background Information

Uniprot Id

Q12923
Target Species

Human
Target Name

PTPN13
Target Full Name

Tyrosine-protein phosphatase non-receptor type 13
Target Function

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2.
Target Subcellular Location

Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium.
Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class subfamily
Target Tissue Specificity

Expressed in keratinocytes (at protein level). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.
Target Synonyms

PTPN13; PNP1; PTP1E; PTPL1; Tyrosine-protein phosphatase non-receptor type 13; EC 3.1.3.48; Fas-associated protein-tyrosine phosphatase 1; FAP-1; PTP-BAS; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1
Target Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

Recombinant Human Tyrosine-protein phosphatase non-receptor type 13 (PTPN13), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Tyrosine-protein phosphatase non-receptor type 13 (PTPN13), Truncated Now

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