Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), Truncated

Cat.No	ACP00539	Target Name	PTPN14
Target Synonyms	Protein-tyrosine phosphatase pez	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-189aa
Mol Weight	29.3 kDa	Protein Length	Partial
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00539

Target Name

PTPN14

Target Synonyms

Protein-tyrosine phosphatase pez

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-189aa

Mol Weight

29.3 kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q15678

Background Information

Uniprot Id

Q15678
Target Species

Human
Target Name

PTPN14
Target Full Name

Tyrosine-protein phosphatase non-receptor type 14
Target Function

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor.
Target Involvement

Choanal atresia and lymphedema (CHATLY)
Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.
Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class subfamily
Target Tissue Specificity

Ubiquitous.
Target Research Area

Signal Transduction
Target Synonyms

Cytoskeletal associated protein tyrosine phosphatase; MGC126803; PEZ; Phosphatase with ezrin domain; Protein tyrosine phosphatase non receptor type 14; Protein tyrosine phosphatase pez; Protein-tyrosine phosphatase pez; PTN14_HUMAN; PTP 36; PTP36; PTPD 2; PTPN 14; PTPN14; Tyrosine protein phosphatase non receptor type 14; Tyrosine-protein phosphatase non-receptor type 14
Target Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.

Recombinant Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), Truncated

Specifications

Immunogen Information

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