Recombinant Human Tyrosine-protein phosphatase non-receptor type 18 (PTPN18)

Uniprot Id

Q99952

Target Species

Human

Target Name

PTPN18

Target Full Name

Tyrosine-protein phosphatase non-receptor type 18

Target Function

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily

Target Tissue Specificity

Expressed in brain, colon and several tumor-derived cell lines.

Target Synonyms

BDP 1; Brain derived phosphatase; Brain-derived phosphatase; Protein tyrosine phosphatase non receptor type 18; Protein tyrosine phosphatase non receptor type 18 brain derived; PTN18_HUMAN; PTP HSCF; PTPN 18; PTPN18; Tyrosine protein phosphatase non receptor type 18; Tyrosine-protein phosphatase non-receptor type 18

Target Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene.