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| Cat.No | ACP02764 | Target Name | LSM4 |
|---|---|---|---|
| Target Synonyms | LSM4U6 snRNA-associated Sm-like protein LSm4; Glycine-rich protein; GRP | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-139aa |
| Mol Weight | 31.3kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y4Z0 |
|---|
Uniprot Id
Q9Y4Z0
Target Species
Human
Target Name
LSM4
Target Full Name
U6 snRNA-associated Sm-like protein LSm4
Target Function
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Target Subcellular Location
Nucleus.
Target Protein Families
SnRNP Sm proteins family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
LSM4U6 snRNA-associated Sm-like protein LSm4; Glycine-rich protein; GRP
Target Background
This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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