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| Cat.No | ACP12470 | Target Name | COQ7 |
|---|---|---|---|
| Target Synonyms | COQ7; 5-demethoxyubiquinone hydroxylase; mitochondrial; DMQ hydroxylase; EC 1.14.13.-; Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 37-217 |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q99807 |
|---|
Uniprot Id
Q99807
Target Species
Human
Target Name
COQ7
Target Full Name
5-demethoxyubiquinone hydroxylase, mitochondrial
Target Function
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
Target Involvement
Coenzyme Q10 deficiency, primary, 8 (COQ10D8)
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Target Protein Families
COQ7 family
Target Tissue Specificity
Expressed dominantly in heart and skeletal muscle.
Target Synonyms
COQ7; 5-demethoxyubiquinone hydroxylase; mitochondrial; DMQ hydroxylase; EC 1.14.13.-; Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7
Target Background
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene.
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