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Recombinant Human Ubiquinone biosynthesis protein COQ7 homolog (COQ7), Truncated

ACP12470

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP12470 Target NameCOQ7
Target SynonymsCOQ7; 5-demethoxyubiquinone hydroxylase; mitochondrial; DMQ hydroxylase; EC 1.14.13.-; Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Expression Range37-217
Protein LengthPartialPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ99807
Background Information
  • Uniprot Id

    Q99807

  • Target Species

    Human

  • Target Name

    COQ7

  • Target Full Name

    5-demethoxyubiquinone hydroxylase, mitochondrial

  • Target Function

    Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.

  • Target Involvement

    Coenzyme Q10 deficiency, primary, 8 (COQ10D8)

  • Target Subcellular Location

    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

  • Target Protein Families

    COQ7 family

  • Target Tissue Specificity

    Expressed dominantly in heart and skeletal muscle.

  • Target Synonyms

    COQ7; 5-demethoxyubiquinone hydroxylase; mitochondrial; DMQ hydroxylase; EC 1.14.13.-; Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7

  • Target Background

    The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene.

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