Recombinant Human Ubiquitin carboxyl-terminal hydrolase 22 (USP22)

Uniprot Id

Q9UPT9

Target Species

Human

Target Name

USP22

Target Full Name

Ubiquitin carboxyl-terminal hydrolase 22

Target Function

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Target Subcellular Location

Nucleus.

Target Protein Families

Peptidase C19 family, UBP8 subfamily

Target Tissue Specificity

Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.

Target Synonyms

Deubiquitinating enzyme 22; KIAA1063; Ubiquitin carboxyl terminal hydrolase 22; Ubiquitin carboxyl-terminal hydrolase 22; Ubiquitin specific peptidase 22; Ubiquitin specific peptidase 3 like; Ubiquitin specific processing protease 22; Ubiquitin specific protease 22; Ubiquitin thioesterase 22; Ubiquitin thiolesterase 22; Ubiquitin-specific-processing protease 22; UBP22_HUMAN; USP 22; Usp22; USP3L

Target Background

Enables enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent deubiquitinase. Contributes to H4 histone acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex.