Recombinant Human Ubiquitin carboxyl-terminal hydrolase 4 (USP4), Truncated

Cat.No	ACP18406	Target Name	USP4
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP18406

Target Name

USP4

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q13107

Background Information

Uniprot Id

Q13107
Target Species

Human
Target Name

USP4
Target Full Name

Ubiquitin carboxyl-terminal hydrolase 4
Target Function

Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

Peptidase C19 family, USP4 subfamily
Target Tissue Specificity

Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.
Target Synonyms

Deubiquitinating enzyme 4; MGC149848; MGC149849; Proto oncogene; Protooncogene; Ubiquitin carboxyl terminal hydrolase 4; Ubiquitin carboxyl-terminal hydrolase 4; Ubiquitin specific peptidase 4 (proto oncogene); Ubiquitin specific peptidase 4 (protooncogene); Ubiquitin specific peptidase 4; Ubiquitin specific processing protease 4; Ubiquitin specific protease 4 (proto oncogene); Ubiquitin specific protease 4 (protooncogene); Ubiquitin specific protease 4; Ubiquitin specific protease proto oncogene; Ubiquitin specific protease protooncogene; Ubiquitin thioesterase 4; Ubiquitin thiolesterase 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein homolog; UBP4_HUMAN; UNP; UNPH; USP 4; USP4
Target Background

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 4 (USP4), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Ubiquitin carboxyl-terminal hydrolase 4 (USP4), Truncated Now

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