Recombinant Human Ubiquitin carboxyl-terminal hydrolase 44 (USP44)

Uniprot Id

Q9H0E7

Target Species

Human

Target Name

USP44

Target Full Name

Ubiquitin carboxyl-terminal hydrolase 44

Target Function

Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.

Target Subcellular Location

Nucleus.

Target Protein Families

Peptidase C19 family, USP44 subfamily

Target Tissue Specificity

Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia.

Target Synonyms

Deubiquitinating enzyme 44; E430004F17Rik; Ubiquitin carboxyl-terminal hydrolase 44; ubiquitin specific peptidase 44; Ubiquitin thiolesterase 44; Ubiquitin-specific-processing protease 44; UBP44_HUMAN; USP44

Target Background

The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome.