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| Cat.No | ACP00381 | Target Name | UBE2J1 |
|---|---|---|---|
| Target Synonyms | E2 ubiquitin-conjugating enzyme J1;Non-canonical ubiquitin-conjugating enzyme 1;NCUBE-1;Yeast ubiquitin-conjugating enzyme UBC6 homolog E;HsUBC6e | Form | Liquid or Lyophilized powder |
| Expression System | Mammalian cell | Expression Range | 1-282aa |
| Mol Weight | 32.5 kDa | Protein Length | Partial |
| Purity | Greater than 95% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y385 |
|---|
Uniprot Id
Q9Y385
Target Species
Human
Target Name
UBE2J1
Target Full Name
Ubiquitin-conjugating enzyme E2 J1
Target Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Target Protein Families
Ubiquitin-conjugating enzyme family
Target Research Area
Cell Biology
Target Synonyms
UBE2J1; NCUBE1; CGI-76; HSPC153; HSPC205; Ubiquitin-conjugating enzyme E2 J1; EC 2.3.2.23; E2 ubiquitin-conjugating enzyme J1; Non-canonical ubiquitin-conjugating enzyme 1; NCUBE-1; Yeast ubiquitin-conjugating enzyme UBC6 homolog E; HsUBC6e
Target Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.
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