Recombinant Human Ubiquitin conjugation factor E4 A (UBE4A), Truncated

Uniprot Id

Q14139

Target Species

Human

Target Name

UBE4A

Target Full Name

Ubiquitin conjugation factor E4 A

Target Function

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Ubiquitin conjugation factor E4 family

Target Synonyms

E4; KIAA0126; MGC133315; UBE4A; UBE4A_HUMAN; Ubiquitin conjugation factor E4 A; ubiquitination factor E4A (UFD2 homolog yeast); Ubiquitination factor E4A; UBOX2; UFD2; UFD2 homolog; UFD2b

Target Background

This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.