Recombinant Human Ubiquitin-like modifier-activating enzyme 7 (UBA7), Truncated

Uniprot Id

P41226

Target Species

Human

Target Name

UBA7

Target Full Name

Ubiquitin-like modifier-activating enzyme 7

Target Function

Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Target Protein Families

Ubiquitin-activating E1 family

Target Tissue Specificity

Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.

Target Synonyms

D8; MGC12713; UBA1, ubiquitin activating enzyme E1 homolog B; UBA1B; UBA7; UBA7, ubiquitin activating enzyme E1; UBA7_HUMAN; Ube 1L; UBE 2; UBE1L; UBE2; Ubiquitin activating enzyme 2; Ubiquitin activating enzyme E1 homolog; Ubiquitin Activating Enzyme E1 Like; Ubiquitin activating enzyme E1 related protein; Ubiquitin-activating enzyme 7; Ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme-2; ubiquitin-like modifier activating enzyme 7; Ubiquitin-like modifier-activating enzyme 7

Target Background

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.