Recombinant Human UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (B3GNT7), Truncated

Uniprot Id

Q8NFL0

Target Species

Human

Target Name

B3GNT7

Target Full Name

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

Target Function

N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency. May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion

Target Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Target Protein Families

Glycosyltransferase 31 family

Target Tissue Specificity

Expressed in corneal epithelial cells.

Target Research Area

Tags & Cell Markers

Target Synonyms

3-Gn-T7; 3-N-acetylglucosaminyltransferase 7; B3GN7_HUMAN; B3gnt7; Beta 1 3 N acetylglucosaminyltransferase 7; Beta-1; Beta3Gn T7; Beta3Gn-T7; beta3GnT7; BGnT 7; BGnT-7; UDP GlcNAc betaGal beta 1 3 N acetylglucosaminyltransferase 7; UDP-GlcNAc:betaGal beta-1