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| Cat.No | ACP17306 | Target Name | CMPK2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 99-449 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5EBM0 |
|---|
Uniprot Id
Q5EBM0
Target Species
Human
Target Name
CMPK2
Target Full Name
UMP-CMP kinase 2, mitochondrial
Target Function
May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity.
Target Subcellular Location
Mitochondrion.
Target Protein Families
Thymidylate kinase family
Target Tissue Specificity
Among all investigated tumors, leukemia cells show the most abundant expression.
Target Synonyms
1200004E04Rik; Cmpk2; CMPK2_HUMAN; Cytidine monophosphate (UMP CMP) kinase 2; mitochondrial; mitochondrial; Mitochondrial UMP CMP kinase; OTTHUMP00000200305; Thymidine monophosphate kinase 2; TMPK2; TYKi; UMP CMP kinase 2; mitochondrial; UMP CMP kinase 2; mitochondrial; cytidylate kinase 2; UMP CMPK2; UMP-CMP kinase 2
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