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| Cat.No | ACP11097 | Target Name | MGME1 |
|---|---|---|---|
| Target Synonyms | MGME1; C20orf72; DDK1Mitochondrial genome maintenance exonuclease 1; EC 3.1.-.- | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BQP7 |
|---|
Uniprot Id
Q9BQP7
Target Species
Human
Target Name
MGME1
Target Full Name
Mitochondrial genome maintenance exonuclease 1
Target Function
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.
Target Involvement
Mitochondrial DNA depletion syndrome 11 (MTDPS11)
Target Subcellular Location
Mitochondrion.
Target Protein Families
MGME1 family
Target Synonyms
MGME1; C20orf72; DDK1Mitochondrial genome maintenance exonuclease 1; EC 3.1.-.-
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