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| Cat.No | ACP15681 | Target Name | CXorf67 |
|---|---|---|---|
| Target Synonyms | EZHIP; CXorf67EZH inhibitory protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-503 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86X51 |
|---|
Uniprot Id
Q86X51
Target Species
Human
Target Name
EZHIP
Target Full Name
EZH inhibitory protein
Target Function
Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2. Inhibits H3K27me3 deposition during spermatogenesis and oogenesis.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Tissue Specificity
In testis, detected in male germ cells inside the seminiferous tubules, especially in spermatogonia and round spermatids (at protein level). In the ovary, expressed in primordial follicles and oocytes but not the external follicle cells (at protein level)
Target Synonyms
EZHIP; CXorf67EZH inhibitory protein
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