Home Products Recombinant Human Uncharacterized protein KIAA0226-like (KIAA0226L)

Recombinant Human Uncharacterized protein KIAA0226-like (KIAA0226L)

ACP10643

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Specifications

Cat.No	ACP10643	Target Name	RUBCNL
Target Synonyms	C13orf18; CM018_HUMAN; FLJ21562; FLJ43762 ; KIAA0226 like; KIAA0226L; RP11-247M1.4; Uncharacterized protein C13orf18; Uncharacterized protein KIAA0226-like	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-662
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9H714

Background Information

Uniprot Id

Q9H714
Target Species

Human
Target Name

RUBCNL
Target Full Name

Protein associated with UVRAG as autophagy enhancer
Target Function

Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis. May act as a tumor suppressor.
Target Subcellular Location

Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
Target Tissue Specificity

Expressed weakly in cervical carcinoma cell lines.
Target Synonyms

C13orf18; CM018_HUMAN; FLJ21562; FLJ43762 ; KIAA0226 like; KIAA0226L; RP11-247M1.4; Uncharacterized protein C13orf18; Uncharacterized protein KIAA0226-like

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Recombinant Human Uncharacterized protein KIAA0226-like (KIAA0226L)

Specifications

Immunogen Information

Inquire Recombinant Human Uncharacterized protein KIAA0226-like (KIAA0226L) Now

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