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| Cat.No | ACP16094 | Target Name | LYPD8 |
|---|---|---|---|
| Target Synonyms | LOC646627 ; Phospholipase inhibitor ; Uncharacterized protein UNQ511/PRO1026; YA003_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 20-215 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6UX82 |
|---|
Uniprot Id
Q6UX82
Target Species
Human
Target Name
LYPD8
Target Full Name
Ly6/PLAUR domain-containing protein 8
Target Function
Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
Target Protein Families
CNF-like-inhibitor family
Target Tissue Specificity
Expressed in the large intestine. Preferentially expressed on the epithelial layer exposed to the lumen (at protein level).
Target Synonyms
LOC646627 ; Phospholipase inhibitor ; Uncharacterized protein UNQ511/PRO1026; YA003_HUMAN
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