Recombinant Human Unconventional myosin-IXb (MYO9B), Truncated

Uniprot Id

Q13459

Target Species

Human

Target Name

MYO9B

Target Full Name

Unconventional myosin-IXb

Target Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA.

Target Involvement

Celiac disease 4 (CELIAC4)

Target Subcellular Location

Cytoplasm, cell cortex. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family

Target Tissue Specificity

Detected in peripheral blood leukocytes (at protein level). Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung.

Target Synonyms

MYO9B; MYR5; Unconventional myosin-IXb; Unconventional myosin-9b