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| Cat.No | ACP06875 | Target Name | TMEM258 |
|---|---|---|---|
| Target Synonyms | TMEM258; C11orf10; HSPC005; Transmembrane protein 258; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258; Oligosaccharyl transferase subunit TMEM258 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P61165 |
|---|
Uniprot Id
P61165
Target Species
Human
Target Name
TMEM258
Target Full Name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
Target Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Involved in ER homeostasis in the colonic epithelium
Target Subcellular Location
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Target Protein Families
TMEM258 family
Target Tissue Specificity
Ubiquitously expressed.
Target Synonyms
TMEM258; C11orf10; HSPC005; Transmembrane protein 258; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258; Oligosaccharyl transferase subunit TMEM258
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