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| Cat.No | ACP14362 | Target Name | C12orf66 |
|---|---|---|---|
| Target Synonyms | C12orf66KICSTOR complex protein C12orf66 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-445 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96MD2 |
|---|
Uniprot Id
Q96MD2
Target Species
Human
Target Name
KICS2
Target Full Name
KICSTOR subunit 2
Target Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Target Subcellular Location
Lysosome membrane.
Target Protein Families
UPF0536 family
Target Synonyms
C12orf66KICSTOR complex protein C12orf66
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