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The process for recombinant Human PLAU protein synthesis in e.coli cells includes recombining the DNA fragment that encodes the Human PLAU protein (21-431aa) into expression vector, transforming the recombinant vector into e.coli cells, screening positive cells, cultivating and inducing cells, conducting cell lysis, and performing expression analysis. The resulting recombinant Human PLAU protein is purified from the cell lysate using affinity purification, with its purity exceeding 85% as determined by SDS-PAGE.
The process for recombinant Human PLAU protein synthesis in e.coli cells includes recombining the DNA fragment that encodes the Human PLAU protein (21-431aa) into expression vector, transforming the recombinant vector into e.coli cells, screening positive cells, cultivating and inducing cells, conducting cell lysis, and performing expression analysis. The resulting recombinant Human PLAU protein is purified from the cell lysate using affinity purification, with its purity exceeding 85% as determined by SDS-PAGE.
| Cat.No | ACP04949 | Target Name | PLAU |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 21-431aa | Mol Weight | 52.4 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P00749 |
|---|
Uniprot Id
P00749
Target Species
Human
Target Name
PLAU
Target Full Name
Urokinase-type plasminogen activator
Target Function
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Target Involvement
Quebec platelet disorder (QPD)
Target Subcellular Location
Secreted.
Target Protein Families
Peptidase S1 family
Target Tissue Specificity
Expressed in the prostate gland and prostate cancers.
Target Research Area
Cardiovascular
Target Synonyms
ATF; ATF uPA; BDPLT5; Plasminogen activator; Plasminogen activator urinary; Plasminogen activator urokinase; PLAU; QPD; u PA; U plasminogen activator; u-PA; U-plasminogen activator; uPA; URK; UROK_HUMAN; Urokinase plasminogen activator; Urokinase type plasminogen activator; Urokinase type plasminogen activator precursor; Urokinase-type plasminogen activator chain B
Target Background
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
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