Recombinant Human V-set domain-containing T-cell activation inhibitor 1 (VTCN1), Truncated

Cat.No	ACP15297	Target Name	VTCN1
Target Synonyms	B7 family member, H4; B7 H4; B7 homolog 4; B7 superfamily member 1; B7 superfamily	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP15297

Target Name

VTCN1

Target Synonyms

B7 family member, H4; B7 H4; B7 homolog 4; B7 superfamily member 1; B7 superfamily

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q7Z7D3

Background Information

Uniprot Id

Q7Z7D3
Target Species

Human
Target Name

VTCN1
Target Full Name

V-set domain-containing T-cell activation inhibitor 1
Target Function

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.
Target Protein Families

Immunoglobulin superfamily, BTN/MOG family
Target Tissue Specificity

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, i
Target Research Area

Immunology
Target Synonyms

B7 family member, H4; B7 H4; B7 homolog 4; B7 superfamily member 1; B7 superfamily, member 1; B7-H4; B7h.5; B7h4; B7S1; B7x; BC032925; Immune costimulatory protein B7-H4; Immune costimulatory protein B7H4; MGC41287; PRO1291; Protein B7S1; RP11 229A19.4; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; V set domain-containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; VCTN1; Vtcn1; VTCN1_HUMAN
Target Background

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.

Recombinant Human V-set domain-containing T-cell activation inhibitor 1 (VTCN1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human V-set domain-containing T-cell activation inhibitor 1 (VTCN1), Truncated Now

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