Recombinant Human VIP36-like protein (LMAN2L), Truncated

Uniprot Id

Q9H0V9

Target Species

Human

Target Name

LMAN2L

Target Full Name

VIP36-like protein

Target Function

May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.

Target Involvement

Mental retardation, autosomal recessive 52 (MRT52)

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.

Target Tissue Specificity

Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.

Target Synonyms

LMAN2L; VIPL; PSEC0028; UNQ368/PRO704; VIP36-like protein; Lectin mannose-binding 2-like; LMAN2-like protein

Target Background

This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway.