Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2), Truncated

Uniprot Id

Q9NY47

Target Species

Human

Target Name

CACNA2D2

Target Full Name

Voltage-dependent calcium channel subunit alpha-2/delta-2

Target Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Calcium channel subunit alpha-2/delta family

Target Tissue Specificity

Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta an

Target Synonyms

Alpha 2 delta calcium channel subunit ; CA2D2_HUMAN; CACNA2D; Cacna2d2; Calcium channel, voltage-dependent, alpha 2/delta subunit 2; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26; Calcium voltage gated channel auxiliary subunit alpha2delta 2; Gene 26; KIAA0558; LUAC11.1; Voltage-dependent calcium channel subunit alpha-2/delta-2; Voltage-dependent calcium channel subunit delta-2; Voltage-gated calcium channel subunit alpha-2/delta-2

Target Background

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.