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| Cat.No | ACP17788 | Target Name | WASHC5 |
|---|---|---|---|
| Target Synonyms | KIAA0196; SPG8; STRUM_HUMAN; WASH complex subunit strumpellin | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q12768 |
|---|
Uniprot Id
Q12768
Target Species
Human
Target Name
WASHC5
Target Full Name
WASH complex subunit 5
Target Function
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7.
Target Involvement
Spastic paraplegia 8, autosomal dominant (SPG8); Ritscher-Schinzel syndrome 1 (RTSC1)
Target Subcellular Location
Cytoplasm, cytosol. Endoplasmic reticulum. Early endosome.
Target Protein Families
Strumpellin family
Target Tissue Specificity
Expressed ubiquitously.
Target Synonyms
KIAA0196; SPG8; STRUM_HUMAN; WASH complex subunit strumpellin
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