Recombinant Human WD repeat-containing protein 11 (WDR11), Truncated

Uniprot Id

Q9BZH6

Target Species

Human

Target Name

WDR11

Target Full Name

WD repeat-containing protein 11

Target Function

Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1.

Target Involvement

Hypogonadotropic hypogonadism 14 with or without anosmia (HH14)

Target Subcellular Location

Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network.

Target Tissue Specificity

Ubiquitous.

Target Synonyms

WDR11; BRWD2; KIAA1351; WDR15WD repeat-containing protein 11; Bromodomain and WD repeat-containing protein 2; WD repeat-containing protein 15

Target Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.