Recombinant Human WD repeat-containing protein 18 (WDR18)

Uniprot Id

Q9BV38

Target Species

Human

Target Name

WDR18

Target Full Name

WD repeat-containing protein 18

Target Function

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development.

Target Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Dynein axonemal particle.

Target Protein Families

WD repeat IPI3/WDR18 family

Target Synonyms

Involved in Processing ITS2 3 homolog; Ipi3; MGC2436; R32184_1; WD repeat domain 18; WD repeat-containing protein 18; Wdr18; WDR18_HUMAN

Target Background

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.