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| Cat.No | ACP12076 | Target Name | WDR41 |
|---|---|---|---|
| Target Synonyms | FLJ10904; MSTP048; WD repeat domain 41; WD repeat protein 41; WD repeat-containing protein 41; WDR 41; WDR41; WDR41_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-459 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HAD4 |
|---|
Uniprot Id
Q9HAD4
Target Species
Human
Target Name
WDR41
Target Full Name
WD repeat-containing protein 41
Target Function
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
Target Subcellular Location
Cytoplasm.
Target Synonyms
FLJ10904; MSTP048; WD repeat domain 41; WD repeat protein 41; WD repeat-containing protein 41; WDR 41; WDR41; WDR41_HUMAN
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