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| Cat.No | ACP21313 | Target Name | WDR62 |
|---|---|---|---|
| Target Synonyms | WDR62; C19orf14; WD repeat-containing protein 62 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O43379 |
|---|
Uniprot Id
O43379
Target Species
Human
Target Name
WDR62
Target Full Name
WD repeat-containing protein 62
Target Function
Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication.
Target Involvement
Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2)
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Target Tissue Specificity
Present in fetal brain, enriched within the ventricular and subventricular zone (at protein level). In the embryonic brain it is expressed in mitotic neural precursor cells.
Target Synonyms
WDR62; C19orf14; WD repeat-containing protein 62
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