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| Cat.No | ACP11989 | Target Name | MIOS |
|---|---|---|---|
| Target Synonyms | MIOS; GATOR complex protein MIOS; Missing oocyte meiosis regulator homolog | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NXC5 |
|---|
Uniprot Id
Q9NXC5
Target Species
Human
Target Name
MIOS
Target Full Name
GATOR2 complex protein MIOS
Target Function
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1.
Target Subcellular Location
Lysosome membrane.
Target Protein Families
WD repeat mio family
Target Synonyms
MIOS; GATOR complex protein MIOS; Missing oocyte meiosis regulator homolog
Target Background
Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and protein-containing complex localization. Located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Part of GATOR2 complex.
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