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Recombinant Human Wee1-like protein kinase 2 (WEE2)

ACP20421

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Specifications

Cat.No	ACP20421	Target Name	WEE2
Target Synonyms	hCG_39453; WEE1 homolog 2 (S. pombe); Wee1-like protein kinase 1B; Wee1-like protein kinase 2; WEE1B; Wee1B kinase; Wee2; WEE2_HUMAN	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-567
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P0C1S8

Background Information

Uniprot Id

P0C1S8
Target Species

Human
Target Name

WEE2
Target Full Name

Wee1-like protein kinase 2
Target Function

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Target Subcellular Location

Nucleus.
Target Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
Target Tissue Specificity

Expressed in oocytes (at protein level). May also be expressed in testis.
Target Synonyms

hCG_39453; WEE1 homolog 2 (S. pombe); Wee1-like protein kinase 1B; Wee1-like protein kinase 2; WEE1B; Wee1B kinase; Wee2; WEE2_HUMAN

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Recombinant Human Wee1-like protein kinase 2 (WEE2)

Specifications

Immunogen Information

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