Recombinant Human Wilms tumor protein 1-interacting protein (WTIP)

Uniprot Id

A6NIX2

Target Species

Human

Target Name

WTIP

Target Full Name

Wilms tumor protein 1-interacting protein

Target Function

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body. Involved in cilia growth and positioning

Target Subcellular Location

Cell junction, adherens junction. Nucleus. Cytoplasm, P-body.

Target Protein Families

Zyxin/ajuba family

Target Synonyms

WTIP; Wilms tumor protein 1-interacting protein; WT1-interacting protein