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Introducing our Recombinant Human WT1 protein, expertly crafted to support your transcription research endeavors. This full-length Wilms tumor protein (WT33) is expressed in an E. coli system, encompassing the 1-449aa region to ensure optimal functionality in your experiments. Equipped with an N-terminal 6xHis-SUMO tag, this protein facilitates streamlined purification and detection processes. Our Recombinant Human WT1 protein exhibits a purity greater than 90% as determined by SDS-PAGE, and is available in both liquid and lyophilized powder forms to cater to your specific research needs. Rely on our precision-engineered WT1 protein to deliver consistent, high-quality results for your transcription studies.
Introducing our Recombinant Human WT1 protein, expertly crafted to support your transcription research endeavors. This full-length Wilms tumor protein (WT33) is expressed in an E. coli system, encompassing the 1-449aa region to ensure optimal functionality in your experiments.
Equipped with an N-terminal 6xHis-SUMO tag, this protein facilitates streamlined purification and detection processes. Our Recombinant Human WT1 protein exhibits a purity greater than 90% as determined by SDS-PAGE, and is available in both liquid and lyophilized powder forms to cater to your specific research needs. Rely on our precision-engineered WT1 protein to deliver consistent, high-quality results for your transcription studies.
| Cat.No | ACP02667 | Target Name | WT1 |
|---|---|---|---|
| Target Synonyms | WIT 2; WT 1; AWT1; FWT1; GUD; NPHS4; WAGR; Wilms tumor 1; Wilms Tumor; Wilms tumor protein; Wilms' tumor gene; Wilms' tumor protein; WIT2; WT; WT1; WT1_HUMAN; WT33 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-449aa |
| Mol Weight | 65.2kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P19544 |
|---|
Uniprot Id
P19544
Target Species
Human
Target Name
WT1
Target Full Name
Wilms tumor protein
Target Function
Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Target Involvement
Frasier syndrome (FS); Wilms tumor 1 (WT1); Denys-Drash syndrome (DDS); Nephrotic syndrome 4 (NPHS4); Meacham syndrome (MEACHS); Mesothelioma, malignant (MESOM)
Target Subcellular Location
Nucleus. Nucleus, nucleolus. Cytoplasm.; [Isoform 1]: Nucleus speckle.; [Isoform 4]: Nucleus, nucleoplasm.
Target Protein Families
EGR C2H2-type zinc-finger protein family
Target Tissue Specificity
Expressed in the kidney and a subset of hematopoietic cells.
Target Research Area
Cancer, Transcription
Target Synonyms
WIT 2; WT 1; AWT1; FWT1; GUD; NPHS4; WAGR; Wilms tumor 1; Wilms Tumor; Wilms tumor protein; Wilms' tumor gene; Wilms' tumor protein; WIT2; WT; WT1; WT1_HUMAN; WT33
Target Background
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
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