Recombinant Human WW domain-binding protein 2 (WBP2)

Uniprot Id

Q969T9

Target Species

Human

Target Name

WBP2

Target Full Name

WW domain-binding protein 2

Target Function

Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR.

Target Involvement

Deafness, autosomal recessive, 107 (DFNB107)

Target Subcellular Location

Cytoplasm. Nucleus.

Target Tissue Specificity

Ubiquitous.

Target Synonyms

MGC18269; WBP 2; WBP-2; Wbp2; WBP2_HUMAN; WW domain binding protein 2; WW domain-binding protein 2

Target Background

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment.