Recombinant Human Xanthine dehydrogenase/oxidase (XDH), Truncated

Uniprot Id

P47989

Target Species

Human

Target Name

XDH

Target Full Name

Xanthine dehydrogenase/oxidase

Target Function

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).

Target Involvement

Xanthinuria 1 (XAN1)

Target Subcellular Location

Cytoplasm. Peroxisome. Secreted.

Target Protein Families

Xanthine dehydrogenase family

Target Tissue Specificity

Detected in milk (at protein level).

Target Synonyms

Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase; Xanthine oxidase; Xanthine oxidoreductase; XD; XDH; XDH_HUMAN; xdha; XO; xor

Target Background

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.