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| Cat.No | ACP15959 | Target Name | ZBTB49 |
|---|---|---|---|
| Target Synonyms | ZBTB49; ZNF509Zinc finger and BTB domain-containing protein 49; Zinc finger protein 509 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-765 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6ZSB9 |
|---|
Uniprot Id
Q6ZSB9
Target Species
Human
Target Name
ZBTB49
Target Full Name
Zinc finger and BTB domain-containing protein 49
Target Function
Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.; Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).; Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.
Target Subcellular Location
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.
Target Protein Families
Krueppel C2H2-type zinc-finger protein family
Target Tissue Specificity
Highly expressed in normal epidermis and in other epithelial tissues, including in colon and lung. Tends to be down-regulated in colon, lung and skin cancer tissues.
Target Synonyms
ZBTB49; ZNF509Zinc finger and BTB domain-containing protein 49; Zinc finger protein 509
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