Recombinant Human Zinc finger protein 268 (ZNF268), Truncated

Uniprot Id

Q14587

Target Species

Human

Target Name

ZNF268

Target Full Name

Zinc finger protein 268

Target Function

Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.

Target Subcellular Location

[Isoform 1]: Nucleus.; [Isoform 2]: Nucleus. Cytoplasm.

Target Protein Families

Krueppel C2H2-type zinc-finger protein family

Target Tissue Specificity

Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform

Target Synonyms

ZNF268Zinc finger protein 268; Zinc finger protein HZF3

Target Background

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of NIK/NF-kappaB signaling; positive regulation of nitrogen compound metabolic process; and regulation of apoptotic process. Located in actin cytoskeleton; cytosol; and nucleus.