Recombinant Human Zinc finger protein 304 (ZNF304)

Cat.No	ACP19048	Target Name	ZNF304
Target Synonyms	MGC129703; MGC129704; Zinc finger protein 304; ZN304_HUMAN; ZNF 304; ZNF304	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-659
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP19048

Target Name

ZNF304

Target Synonyms

MGC129703; MGC129704; Zinc finger protein 304; ZN304_HUMAN; ZNF 304; ZNF304

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-659

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9HCX3

Background Information

Uniprot Id

Q9HCX3
Target Species

Human
Target Name

ZNF304
Target Full Name

Zinc finger protein 304
Target Function

Acts as transcriptional regulator and plays a role in gene silencing. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3) in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites. Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways. Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression. Promotes angiogenesis. Promotes tumor growth
Target Subcellular Location

Nucleus.
Target Protein Families

Krueppel C2H2-type zinc-finger protein family
Target Tissue Specificity

Expressed in undifferentiated embryonic stem cells (ESCs). Expressed strongly in colorectal cancers cells (CRCs). Expressed strongly in ovarian carcinoma (OC) tumor cell lines compared to non-transformed ovarian epithelial cells (at protein level). Expres
Target Synonyms

MGC129703; MGC129704; Zinc finger protein 304; ZN304_HUMAN; ZNF 304; ZNF304

Recombinant Human Zinc finger protein 304 (ZNF304)

Specifications

Immunogen Information

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