Recombinant Human Zinc finger protein 521 (ZNF521), Truncated

Cat.No	ACP19313	Target Name	ZNF521
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP19313

Target Name

ZNF521

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96K83

Background Information

Uniprot Id

Q96K83
Target Species

Human
Target Name

ZNF521
Target Full Name

Zinc finger protein 521
Target Function

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes.
Target Involvement

A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521.
Target Subcellular Location

Nucleus.
Target Protein Families

Krueppel C2H2-type zinc-finger protein family
Target Tissue Specificity

Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abund
Target Synonyms

B930086A16Rik; DKFZp564D0764; Early hematopoietic zinc finger; Early hematopoietic zinc finger protein; EHZF; Evi3; LYST-interacting protein 3; MGC142182; MGC142208; Zfp521; Zinc finger protein 521; ZN521_HUMAN; Znf521
Target Background

Enables protein domain specific binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within neuron fate commitment. Located in nucleus.

Recombinant Human Zinc finger protein 521 (ZNF521), Truncated

Specifications

Immunogen Information

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