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| Cat.No | ACP05943 | Target Name | SLC30A5 |
|---|---|---|---|
| Target Synonyms | SLC30A5; ZNT5; ZNTL1; ZTL1; UNQ863/PRO1879Zinc transporter 5; ZnT-5; Solute carrier family 30 member 5; ZnT-like transporter 1; hZTL1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8TAD4 |
|---|
Uniprot Id
Q8TAD4
Target Species
Human
Target Name
SLC30A5
Target Full Name
Proton-coupled zinc antiporter SLC30A5
Target Function
Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
Target Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.
Target Protein Families
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
Target Tissue Specificity
Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.
Target Synonyms
SLC30A5; ZNT5; ZNTL1; ZTL1; UNQ863/PRO1879Zinc transporter 5; ZnT-5; Solute carrier family 30 member 5; ZnT-like transporter 1; hZTL1
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