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The antibody against RRP6 was raised in rabbit using the Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RRP6 protein as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein A/G purified. This antibody has been validated on ELISA, WB.
The antibody against RRP6 was raised in rabbit using the Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker’s yeast) RRP6 protein as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein A/G purified. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in Recombinant protein | All lanes: RRP6 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 54.7 kDa | Observed band size: 58 kDa
| Cat.No | ADC-05237A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RRP6 |
| Target Synonyms | RRP6 antibody; UNC733 antibody; YOR001W antibody; Exosome complex exonuclease RRP6 antibody; EC 3.1.13.- antibody; Ribosomal RNA-processing protein 6 antibody | Form | Liquid |
| Species Reactivity | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Protein A/G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RRP6 protein | Target Species | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q12149 |
Uniprot Id
Q12149
Target Species
Yeast
Target Name
RRP6
Target Function
Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site.
Target Subcellular Location
Nucleus, nucleolus.
Target Protein Families
Exosome component 10/RRP6 family
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