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The antibody against WSS1 was raised in rabbit using the Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against WSS1 was raised in rabbit using the Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
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| Cat.No | ADC-10571A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | WSS1 |
| Form | Liquid | Species Reactivity | Saccharomyces cerevisiae |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA) | Target Species | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P38838 |
Uniprot Id
P38838
Target Species
Yeast
Target Name
WSS1
Target Function
Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
Target Subcellular Location
Nucleus. Note=Present in a single sharp spot near the nuclear membrane, distinct from the spindle pole bodies and nucleolus. In dividing cells, the spot is exclusively present in the mother cell.
Target Protein Families
Peptidase M3 family, WSS1-like metalloprotease (WLM) subfamily
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