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The recombinant antibody against SLC7A11 Recombinant was produced using the Recombinant Human SLC7A11 protein as the immunogen. This antibody exists as a non-conjugated isotype hIgG1, Affinity-chromatography purified. This antibody has been validated on ELISA.
The recombinant antibody against SLC7A11 Recombinant was produced using the Recombinant Human SLC7A11 protein as the immunogen. This antibody exists as a non-conjugated isotype hIgG1, Affinity-chromatography purified. This antibody has been validated on ELISA.
$350.00
| Cat.No | ADC-56119A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | SLC7A11 Recombinant | Target Synonyms | SLC7A11; Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT |
| Form | Liquid | Species Reactivity | Human |
| Isotype | hIgG1 | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human SLC7A11 protein | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UPY5 |
Uniprot Id
Q9UPY5
Target Species
Human
Target Name
SLC7A11
Target Full Name
Cystine/glutamate transporter
Target Function
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Target Synonyms
SLC7A11; Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT
Target Background
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
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