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The recombinant antibody against THBD was produced using a synthesized peptide derived from human THBD as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC.
The recombinant antibody against THBD was produced using a synthesized peptide derived from human THBD as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC.
$350.00
| Cat.No | ADC-56646A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | THBD | Target Synonyms | THBD, THRM, Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141) |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human THBD | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P07204 |
Uniprot Id
P07204
Target Species
Human
Target Name
THBD
Target Full Name
Thrombomodulin
Target Function
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Target Involvement
Thrombophilia due to thrombomodulin defect (THPH12); Hemolytic uremic syndrome atypical 6 (AHUS6)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Endothelial cells are unique in synthesizing thrombomodulin.
Target Research Area
Cardiovascular
Target Synonyms
THBD; THRM; Thrombomodulin; TM; Fetomodulin; CD antigen CD141
Target Background
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
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