Calcium/Calmodulin-Dependent Protein Kinase Type 1D (CAMK1D) Reagents

Calcium/calmodulin-dependent protein kinase type 1D

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily

Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes.

A630059D12Rik; Calcium/calmodulin dependent protein kinase ID ; Calcium/calmodulin dependent protein kinase type 1D; Calcium/calmodulin-dependent protein kinase I-delta; Calcium/calmodulin-dependent protein kinase type 1D; CaM K1; CaM KI delta ; CaM kinase I delta; CaM kinase ID; CaM-KI delta; CAMK 1D; CAMK1D; CaMKI delta; CamKI like protein kinase; CamKI-like protein kinase; CaMKID ; CKLiK; E030025C11Rik; KCC1D_HUMAN; OTTHUMP00000019119; OTTHUMP00000019120; OTTHUMP00000045030; RP11 462F15.1

This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.